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8-letter words (2 found)
DEFRIEND,FRIENDED,
7-letter words (6 found)
DEFINED,DEFINER,ENFIRED,FENDIER,NEDDIER,REFINED,
6-letter words (32 found)
DEFEND,DEFIED,DEFIER,DEFINE,DEIDER,DEIFER,DENIED,DENIER,DERIDE,DERNED,DIEDRE,ENFIRE,FEERIN,FENDED,FENDER,FERINE,FINDER,FINEER,FRIEND,INDEED,INFEED,INFERE,NEREID,REDDEN,REDFIN,REFIND,REFINE,REINED,RENDED,RENIED,RIDDEN,RINDED,
5-letter words (23 found)
DEFER,DERED,DIENE,DINED,DINER,DREED,DRIED,EIDER,ENDED,ENDER,ERNED,FIEND,FIERE,FINED,FINER,FIRED,FREED,FRIED,INFER,NIDED,REDED,REDID,REFED,
4-letter words (53 found)
DEED,DEEN,DEER,DEFI,DEID,DEIF,DENE,DENI,DERE,DERN,DIED,DINE,DIRE,DREE,EIDE,EINE,ERED,ERNE,FEED,FEEN,FEER,FEND,FENI,FERE,FERN,FIER,FIND,FINE,FIRE,FIRN,FREE,IDEE,IRED,NEED,NEIF,NERD,NIDE,NIED,NIEF,NIFE,REDD,REDE,REED,REEF,REEN,REFI,REIF,REIN,REND,RIDE,RIFE,RIND,RINE,
3-letter words (37 found)
DEE,DEF,DEI,DEN,DID,DIE,DIF,DIN,EEN,END,ENE,ERE,ERF,ERN,FED,FEE,FEN,FER,FID,FIE,FIN,FIR,IDE,IRE,NED,NEE,NEF,NID,NIE,RED,REE,REF,REI,REN,RID,RIF,RIN,
2-letter words (13 found)
DE,DI,ED,EE,EF,EN,ER,FE,ID,IF,IN,NE,RE,
1-letter words (1 found)
E,
You can make 167 words from defriend according to the Scrabble US and Canada dictionary.