You can make 165 valid words from the letters in SPEIRED using the Scrabble US/CAN dictionary.
How many points is SPEIRED worth in Scrabble?
SPEIRED is worth 10 points in Scrabble (US/CAN) and 11 points in Words With Friends.
How do I use the Word Unscrambler tool?
Enter any letters into the input box and press Search. The tool will return every valid English word that can be made from those letters using the dictionary you select.