You can make 165 valid words from the letters in SPIERED using the Scrabble US/CAN dictionary.
How many points is SPIERED worth in Scrabble?
SPIERED is worth 10 points in Scrabble (US/CAN) and 11 points in Words With Friends.
How do I use the Word Unscrambler tool?
Enter any letters into the input box and press Search. The tool will return every valid English word that can be made from those letters using the dictionary you select.