You can make 161 valid words from the letters in POTSIES using the Scrabble US/CAN dictionary.
How many points is POTSIES worth in Scrabble?
POTSIES is worth 9 points in Scrabble (US/CAN) and 10 points in Words With Friends.
How do I use the Word Unscrambler tool?
Enter any letters into the input box and press Search. The tool will return every valid English word that can be made from those letters using the dictionary you select.