You can make 194 valid words from the letters in ZANIEST using the Scrabble US/CAN dictionary.
How many points is ZANIEST worth in Scrabble?
ZANIEST is worth 16 points in Scrabble (US/CAN) and 17 points in Words With Friends.
How do I use the Word Unscrambler tool?
Enter any letters into the input box and press Search. The tool will return every valid English word that can be made from those letters using the dictionary you select.